Cellular allograft for multilevel stand-alone anterior cervical discectomy and fusion

OBJECTIVE Anterior cervical discectomy and fusion (ACDF) is the most common treatment for degenerative disease of spine. Given high rate pseudarthrosis in multilevel stand-alone ACDF, there a need to explore utility novel grafting materials. In this study, authors present single-institution retrospective study patients with spine who underwent ACDF surgery or without cellular allograft supplementation. METHODS prospectively collected database, 28 supplemented (ViviGen) 25 decellularized between 2014 2020 were identified. The primary outcome was radiographic determined by 1-year follow-up CT scan. Secondary outcomes included change Neck Disability Index (NDI) scores visual analog scale neck arm pain. RESULTS 53 mean age ± 0.7 years encompassing 2.6 levels on average. Patient demographics similar two cohorts. cohort, 2 experienced postoperative dysphagia that resolved 3-month follow-up. One patient developed radiculopathy due graft subsidence required posterior foraminotomy. At CT, successful achieved 92.9% (26/28) allograft, compared 84.0% (21/25) allograft. cohort significantly greater improvement NDI score (p < 0.05) other cohort. CONCLUSIONS Cellular low-morbidity bone option ACDF. favorable arthrodesis rates functional complex following